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Literature summary for 1.14.11.27 extracted from

  • Kwon, D.H.; Kang, J.Y.; Joung, H.; Kim, J.Y.; Jeong, A.; Min, H.K.; Shin, S.; Lee, Y.G.; Kim, Y.K.; Seo, S.B.; Kook, H.
    SRF is a nonhistone methylation target of KDM2B and SET7 in the regulation of skeletal muscle differentiation (2021), Exp. Mol. Med., 53, 250-263 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NHM5
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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 Homo sapiens
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skeletal muscle
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
serum response factor N6-methyl-L-lysine165 + 2-oxoglutarate + O2
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 Homo sapiens serum response factor L-lysine165 + succinate + formaldehyde + CO2
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 ?

General Information

General Information Comment Organism
physiological function KDM2B demethylates serum response factor residue K165 to negatively regulate muscle differentiation. KDM2B inhibits skeletal muscle differentiation by inhibiting the transcription of SRF-dependent genes. Both KDM2B and histone methyltransferase SET7 regulate the balance of SRF K165 methylation. SRF K165 methylation is required for the transcriptional activation of SRF and for the promoter occupancy of SRF-dependent genes Homo sapiens