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Literature summary for 1.14.11.21 extracted from

  • Lloyd, M.D.; Merritt, K.D.; Lee, V.; Sewell, T.J.; Wha-Son, B.; Baldwin, J.E.; Schofield, C.J.; Elson, S.W.; Baggaley, K.H.; Nicholson, N.H.
    Product-substrate engineering by bacteria: studies on clavaminate synthase, a trifunctional dioxygenase (1999), Tetrahedron, 55, 10201-10220.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
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guanidinoproclavaminate + succinate + CO2 + H2O
-
?
dihydroclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
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clavaminate + succinate + CO2 + H2O
-
?
additional information Streptomyces clavuligerus biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor ?
-
?
proclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
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dihydroclavaminate + succinate + CO2 + H2O
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus
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recombinant purifed isozyme CS2
-

Reaction

Reaction Comment Organism Reaction ID
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla Streptomyces clavuligerus
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 this reaction is due to a proclavaminate amidinohydrolase, i.e. cla Streptomyces clavuligerus amidinoproclavaminate + succinate + CO2 + H2O
-
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus guanidinoproclavaminate + succinate + CO2 + H2O
-
?
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 hydroxylation Streptomyces clavuligerus guanidinoproclavaminate + succinate + CO2 + H2O
-
?
dihydroclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
dihydroclavaminate + 2-oxoglutarate + O2 cyclization Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
dihydroclavaminate + 2-oxoglutarate + O2 syn-elimination of the requisite hydrogens Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
-
?
additional information specific for 2-oxoglutarate Streptomyces clavuligerus ?
-
?
additional information dependent on O2 and 2-oxoglutarate Streptomyces clavuligerus ?
-
?
additional information biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor Streptomyces clavuligerus ?
-
?
proclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?
proclavaminate + 2-oxoglutarate + O2 saturation Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?

Synonyms

Synonyms Comment Organism
CS
-
Streptomyces clavuligerus