Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Streptomyces clavuligerus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | Streptomyces clavuligerus | involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus | |
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O | reaction mechanism | Streptomyces clavuligerus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | cyclization | Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | 5S) enantiomer | ? | |
additional information | stereospecificity | Streptomyces clavuligerus | ? | - |
? | |
additional information | enzyme has a requirement for the 3-hydroxyl group and is specific for C-5 analogues of proclavaminate | Streptomyces clavuligerus | ? | - |
? | |
additional information | no activity with dehydroproclavaminate and C-5 oxygenated, N-formyl, or N-acetylglycyl proclavaminate derivatives | Streptomyces clavuligerus | ? | - |
? | |
additional information | involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams | Streptomyces clavuligerus | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | specific for the threo-(2S,3R) enantiomer | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CAS | - |
Streptomyces clavuligerus |