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Literature summary for 1.14.11.21 extracted from

  • Elson, S.W.; Baggaley, K.H.; Holland, S.; Nicholson, N.H.; Sime, J.T.; Woroniecki, S.R.
    Studies on the substrate specificity of clavaminic acid synthase and associated enzymes (1992), Bioorg. Med. Chem. Lett., 2, 1503-1508.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Streptomyces clavuligerus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydroclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
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clavaminate + succinate + CO2 + H2O
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?
additional information Streptomyces clavuligerus involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams ?
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?
proclavaminate + 2-oxoglutarate + O2 Streptomyces clavuligerus
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dihydroclavaminate + succinate + CO2 + H2O
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?

Organism

Organism UniProt Comment Textmining
Streptomyces clavuligerus
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-
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Reaction

Reaction Comment Organism Reaction ID
dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus
proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O reaction mechanism Streptomyces clavuligerus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroclavaminate + 2-oxoglutarate + O2
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Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O
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?
dihydroclavaminate + 2-oxoglutarate + O2 cyclization Streptomyces clavuligerus clavaminate + succinate + CO2 + H2O 5S) enantiomer ?
additional information stereospecificity Streptomyces clavuligerus ?
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?
additional information enzyme has a requirement for the 3-hydroxyl group and is specific for C-5 analogues of proclavaminate Streptomyces clavuligerus ?
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?
additional information no activity with dehydroproclavaminate and C-5 oxygenated, N-formyl, or N-acetylglycyl proclavaminate derivatives Streptomyces clavuligerus ?
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?
additional information involved in the conversion of monocyclic beta-lactams into bicyclic beta-lactams Streptomyces clavuligerus ?
-
?
proclavaminate + 2-oxoglutarate + O2
-
Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
-
?
proclavaminate + 2-oxoglutarate + O2 saturation Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
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?
proclavaminate + 2-oxoglutarate + O2 specific for the threo-(2S,3R) enantiomer Streptomyces clavuligerus dihydroclavaminate + succinate + CO2 + H2O
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?

Synonyms

Synonyms Comment Organism
CAS
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Streptomyces clavuligerus