Literature summary for 1.13.11.31 extracted from

Mori, Y.; Kawakami, Y.; Kanzaki, K.; Otsuki, A.; Kimura, Y.; Kanji, H.; Tanaka, R.; Tsukayama, I.; Hojo, N.; Suzuki-Yamamoto, T.; Kawakami, T.; Takahashi, Y.
Arachidonate 12S-lipoxygenase of platelet-type in hepatic stellate cells of methionine and choline-deficient diet-fed mice (2020), J. Biochem., 168, 455-463 .

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Application

Application	Comment	Organism
medicine	activity of 12S-lipoxygenase is hardly observed in liver cytosol of normal chow-fed mice but is clearly detectable in that of nonalcoholic steatohepatitis model mice prepared by feeding a methionine and choline-deficient diet	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	P39655	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	-	Mus musculus	-
liver	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	activity of 12S-lipoxygenase is hardly observed in liver cytosol of normal chow-fed mice but is clearly detectable in that of nonalcoholic steatohepatitis model mice prepared. The expression levels of mRNA and protein of platelet-type 12S-lipoxygenase in the liver of methionine- and choline-deficient diet-fed mice are significantly increased compared with those of normal chow-fed mice. Platelet-type 12S-lipoxygenase colocalizes with alpha-smooth muscle actin as well as vitamin A in the cells distributing along liver sinusoids	Mus musculus

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Release 2023.1 (January 2023)