Application | Comment | Organism |
---|---|---|
medicine | hypoxia increases the formation of endogenous 12-hydroxyeicosatetraenoic acid through stimulation of 12-lipoxygenase. 12-hydroxyeicosatetraenoic acid promotes endothelial cell migration and tube formation, whereas it inhibits the serum deprivation-induced apoptotic responses under hypoxia. The regulatory effects of 12-lipoxygenase/12-hydroxyeicosatetraenoic acid on pulmonary artery endothelial cells, at least in part, depend on phosphatidylinositol 3-kinase (PI3K)/Akt signaling activatio | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q2KMM4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | pulmonary artery endothelial cell | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
pulmonary artery | pulmonary artery endothelial cell | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
Alox12b | - |
Rattus norvegicus |