Literature summary for 1.11.2.2 extracted from

Shamova, E.; Gorudko, I.; Grigorieva, D.; Sokolov, A.; Kokhan, A.; Melnikova, G.; Yafremau, N.; Gusev, S.; Sveshnikova, A.; Vasilyev, V.; Cherenkevich, S.; Panasenko, O.
The effect of myeloperoxidase isoforms on biophysical properties of red blood cells (2020), Mol. Cell. Biochem., 464, 119-130 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-aminobenzoic acid hydrazide	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Cl- + H2O2 + H+	Homo sapiens	-	HClO + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05164	-	-

Purification (Commentary)

Purification (Comment)	Organism
heparin-Sepharose column chromatography, hydrophobic column chromatography, phenyl-Sepharose column chromatography, and Sephacryl S-200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cl- + H2O2 + H+	-	Homo sapiens	HClO + H2O	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
MPO	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the monomeric as well as the dimeric enzyme form bind to the glycophorins A/B and band 3 protein on red blood cell's plasma membrane, that lead to reduced cell resistance to osmotic and acidic hemolysis, reduction in cell elasticity, significant changes in cell volume, morphology, and the conductance of red blood cell plasma membrane ion channels. Furthermore, both dimeric and monomeric enzyme forms lead to phosphatidylserine exposure on the outer leaflet of red blood cell membrane	Homo sapiens

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Release 2023.1 (January 2023)