Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | Mus musculus | - |
HClO + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P11247 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | - |
Mus musculus | HClO + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 83000, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | genetic ablation of the enzyme results in osteoporotic phenotypes and potentiated bone-resorptive capacity in mice. Mechanistically, accumulation of intracellular H2O2 and reactive oxygen species are observed in enzyme deficiency. The increased reactive oxygen species caused by enzyme deficiency contributes to osteoclastogenesis | Mus musculus |
physiological function | the enzyme has a protective role in bone turnover by limiting osteoclastogenesis and bone resorption physiologically through modulating intracellular H2O2 level. Enzyme overexpression suppressed reactive oxygen species production in mouse osteoclast precursors | Mus musculus |