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Literature summary for 1.11.2.2 extracted from

  • Zhao, X.; Lin, S.; Li, H.; Si, S.; Wang, Z.
    Myeloperoxidase controls bone turnover by suppressing osteoclast differentiation through modulating reactive oxygen species level (2021), J. Bone Miner. Res., 36, 591-603 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Mus musculus
-
HClO + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P11247
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
Mus musculus HClO + H2O
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 83000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
MPO
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus

General Information

General Information Comment Organism
malfunction genetic ablation of the enzyme results in osteoporotic phenotypes and potentiated bone-resorptive capacity in mice. Mechanistically, accumulation of intracellular H2O2 and reactive oxygen species are observed in enzyme deficiency. The increased reactive oxygen species caused by enzyme deficiency contributes to osteoclastogenesis Mus musculus
physiological function the enzyme has a protective role in bone turnover by limiting osteoclastogenesis and bone resorption physiologically through modulating intracellular H2O2 level. Enzyme overexpression suppressed reactive oxygen species production in mouse osteoclast precursors Mus musculus