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Literature summary for 1.11.2.2 extracted from

  • Aggarwal, G.; May-Zhang, L.S.; Yermalitsky, V.; Dikalov, S.; Voynov, M.A.; Amarnath, V.; Kon, V.; Linton, M.F.; Vickers, K.C.; Davies, S.S.
    Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity (2021), J. Biol. Chem., 297, 101019 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P05164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MPO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function association of the enzyme with high-density lipoprotein leads to lower paraoxonase 1 (PON1) activity in part via isolevuglandin-mediated modification of PON1, so that isolevuglandin modification of PON1 can contribute to increased risk for atherosclerosis Homo sapiens