Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 100 mM HEPES (pH 7.5), 150 mM NaCl, 20-25% (w/v) PEG3350 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-7-(1,2-diphenylethyl)-1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(1,4-diphenylbutyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(1-phenyl-3-((2-(trifluoromethyl)benzyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(1-phenyl-3-((4-phenylbicyclo[2.2.2]octan-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine trifluoroacetate salt | - |
Homo sapiens | |
(R)-7-(1-phenyl-3-((pyridin-2-ylmethyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(1-phenyl-4-(4-phenylpiperidin-1-yl)butyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(3-((2-fluoroethyl)(4-phenylbicyclo[2.2.2]octan-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(3-(benzylamino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(3-(benzyloxy)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
(R)-7-(3-(methyl(4-phenylbicyclo[2.2.2]octan-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
2-[6-(5-chloro-2-methoxyphenyl)-4-oxo-2-sulfanylidene-3,4-dihydropyrimidin-1(2H)-yl]acetamide | i.e. PF-06282999, irreversible inhibitor | Homo sapiens | |
2-[[3,5-bis(trifluoromethyl)benzyl]amino]-N,4-dihydroxypyrimidine-5-carboxamide | - |
Homo sapiens | |
3-((5-amino-3H-[1,2,3]triazolo[4,5-b] pyridin-7-yl)methyl)benzonitrile | - |
Homo sapiens | |
3-([(2R)-oxolan-2-yl]methyl)-2-sulfanylidene-1,2,3,7-tetrahydro-6H-purin-6-one | i.e. TX4, irreversible inhibitor | Homo sapiens | |
7-((R)-1-phenyl-3-(((1R,3R)-3-phenylcyclopentyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-((R)-1-phenyl-3-(((1R,4S)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-((R)-1-phenyl-3-(((1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-((R)-1-phenyl-3-(((3R,6S)-6-phenyltetrahydro-2H-pyran-3-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-((R)-1-phenyl-3-((trans-4-phenylcyclohexyl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-((R)-3-(((S)-2,3-dihydro-1H-inden-1-yl)amino)-1-phenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(1,4-diphenylpropyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(1-phenyl-3-((1-phenyl-2-oxabicyclo[2.2.2]octan-4-yl)amino)propyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(2-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(2-fluorobenzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(3-(trifluoromethyl)benzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(3-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(3-methoxycarbonylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(3-phenylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(4-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-(naphthalen-2-ylmethyl)-3H-[1,2,3] triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | - |
Homo sapiens | |
tryptamine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Cl- + H2O2 + H+ | Homo sapiens | - |
HClO + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05164 | - |
- |
Purification (Comment) | Organism |
---|---|
Superdex 75 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Amplex Red + H2O2 + H+ | - |
Homo sapiens | resorufin + H2O | - |
? | |
Cl- + H2O2 + H+ | - |
Homo sapiens | HClO + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MPO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000017 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(3-methoxycarbonylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | |
0.000026 | - |
at pH 7.4 and 25°C | Homo sapiens | 3-((5-amino-3H-[1,2,3]triazolo[4,5-b] pyridin-7-yl)methyl)benzonitrile | |
0.000032 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(3-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | |
0.000036 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(benzyloxy)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | |
0.000043 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | |
0.000046 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(2-fluorobenzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | |
0.000077 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(3-phenylbenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | |
0.000188 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(naphthalen-2-ylmethyl)-3H-[1,2,3] triazolo[4,5-b]pyridin-5-amine | |
0.00099 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(2-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine | |
0.001426 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(3-(trifluoromethyl)benzyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine | |
0.0093 | - |
at pH 7.4 and 25°C | Homo sapiens | 7-(4-chlorobenzyl)-3H-[1,2,3]triazolo [4,5-b]pyridin-5-amine |