Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.11.2.2 extracted from

  • Vakhrusheva, T.; Sokolov, A.; Kostevich, V.; Vasilyev, V.; Panasenko, O.
    Enzymatic and bactericidal activity of monomeric and dimeric forms of myeloperoxidase (2018), Biochemistry (Moscow) Suppl. Ser. B, 12, 258-265 .
No PubMed abstract available

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
145000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
HClO + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
heparin-Sepharose column chromatography, phenyl-Sepharose column chromatography, and Sephacryl S-200 HR gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O2 + H+
-
Homo sapiens oxidized 2,2'-azino-bis-(3-ethylbenzthiazole-6-sulfonic acid) + H2O
-
?
Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?
o-dianisidine + H2O2 + H+
-
Homo sapiens oxidized o-dianisidine + H2O
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 75000, mature enzyme, SDS-PAGE Homo sapiens
monomer the dimeric molecule can be cleaved into two monomeric subunits by HOCl, most probably due to oxidation of the disulfide bond between these subunits Homo sapiens

Synonyms

Synonyms Comment Organism
donor: H2O2 oxidoreductase
-
Homo sapiens
MPO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens