Literature summary for 1.11.2.2 extracted from

Gorudko, I.; Grigorieva, D.; Sokolov, A.; Shamova, E.; Kostevich, V.; Kudryavtsev, I.; Syromiatnikova, E.; Vasilyev, V.; Cherenkevich, S.; Panasenko, O.
Neutrophil activation in response to monomeric myeloperoxidase (2018), Biochem. Cell Biol., 96, 592-601 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-aminobenzoic acid hydrazide	-	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
145000	-	gel filtration	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Cl- + H2O2 + H+	Homo sapiens	-	HClO + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05164	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-
neutrophil	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cl- + H2O2 + H+	-	Homo sapiens	HClO + H2O	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 70000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
MPO	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	by binding to beta2-integrin (CD11b/CD18), dimeric enzyme induces neutrophil activation and adhesion augmenting leukocyte accumulation at sites of inflammation. Monomeric enzyme is less efficient than dimeric enzyme at inducing actin cytoskeleton reorganization, cell survival, and neutrophil degranulation. The decomposition of dimeric enzyme into monomers can serve as a regulatory mechanism that controls enzyme-dependent activation of neutrophils and reduces the proinflammatory effects of the enzyme. Enzyme-induced increase in cytosolic calcium is due to both Ca2+ release from endoplasmic reticulum and Ca2+ entry from extracellular space through calcium channels in the plasma membrane	Homo sapiens

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Release 2023.1 (January 2023)