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Literature summary for 1.11.2.2 extracted from

  • Zuurbier, K.W.; van den Berg, J.D.; Van Gelder, B.F.; Muijsers, A.O.
    Human hemi-myeloperoxidase. Initial chlorinating activity at neutral pH, compound II and III formation, and stability towards hypochlorous acid and high temperature (1992), Eur. J. Biochem., 205, 737-742.
    View publication on PubMed
Search for more literature for 1.11.2.2

Inhibitors

Inhibitors Comment Organism Structure
HClO
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 dimeric mature enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
 HClO + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
 Homo sapiens HClO + H2O
-
 ?
monochlorodimedone + H2O2
-
 Homo sapiens dichlorodimedone + H2O
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
donor: H2O2 oxidoreductase
-
 Homo sapiens
hemi-MPO reductive alkylation converts the normal dimeric enzyme into two protomers, hemi-myeloperoxidase Homo sapiens
hemi-myeloperoxidase reductive alkylation converts the normal dimeric enzyme into two protomers, hemi-myeloperoxidase Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
80
-
 at 80°C the native dimeric MPO retains remarkable stability (50% activity left after 72 min), but hemi-MPO has already been inactivated by 50% after 4.5 min Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.032
-
 hemi-MPO, in in 150 mM KCI and 50 mM potassium phosphate pH 7.2, at 20°C Homo sapiens HClO
0.05
-
 dimeric MPO, in in 150 mM KCI and 50 mM potassium phosphate pH 7.2, at 20°C Homo sapiens HClO

General Information

General Information Comment Organism
physiological function MPO is involved in the defence mechanism of the body against microorganisms Homo sapiens