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Literature summary for 1.11.2.2 extracted from

  • Kozik, A.; Golda, A.; Mak, P.; Suder, P.; Silberring, J.; Barbasz, A.; Rapala-Kozik, M.
    Myeloperoxidase-catalyzed oxidative inactivation of human kininogens: the impairment of kinin-precursor and prekallikrein-binding functions (2010), Biol. Chem., 392, 263-274.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm cytoplasmic granule Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Cl- + H2O2 + H+ Homo sapiens
-
HClO + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Cl- + H2O2 + H+
-
Homo sapiens HClO + H2O
-
?

Synonyms

Synonyms Comment Organism
donor:H2O2 oxidoreductase
-
Homo sapiens
MPO
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Homo sapiens

General Information

General Information Comment Organism
physiological function upon the action of the MPO-H2O2-chloride system, two of the major functional activities of kininogens: the susceptibility of high-molecular mass kininogen and low-molecular mass kininogen to kinin-forming action of kallikreins and the prekallikrein-binding capability of high-molecular mass kininogen, are dramatically impaired Homo sapiens