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Literature summary for 1.11.1.23 extracted from

  • Chang, W.C.; Dey, M.; Liu, P.; Mansoorabadi, S.O.; Moon, S.J.; Zhao, Z.K.; Drennan, C.L.; Liu, H.W.
    Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction (2013), Nature, 496, 114-118.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Iron a mononuclear non-heme iron-dependent enzyme Streptomyces wedmorensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2 Streptomyces wedmorensis
-
2-oxopropylphosphonic acid + NAD+ + H2O
-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2 Streptomyces wedmorensis
-
(1R,2S)-epoxypropylphosphonate + NAD+ + H2O i.e. fosfomycin ?

Organism

Organism UniProt Comment Textmining
Streptomyces wedmorensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-hydroxypropylphosphonate + NADH + H+ + O2
-
Streptomyces wedmorensis 2-oxopropylphosphonic acid + NAD+ + H2O
-
?
(S)-2-hydroxypropylphosphonate + NADH + H+ + O2
-
Streptomyces wedmorensis (1R,2S)-epoxypropylphosphonate + NAD+ + H2O i.e. fosfomycin ?

Synonyms

Synonyms Comment Organism
HppE
-
Streptomyces wedmorensis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Streptomyces wedmorensis