Literature summary for 1.1.3.21 extracted from

Hlinkina, T.; Kastsiuk, S.
Correlation between nucleotide substitutions in glycerol-3-phosphate oxidase gene, the level of hydrogen peroxide production, and cytotoxicity of Mycoplasma pneumoniae (2020), Cytol. Genet., 54, 18-22 .

No PubMed abstract available

Search for more literature for 1.1.3.21

Application

Application	Comment	Organism
medicine	isolation of mutants with decreased or increased production of H2O2 from children and teens with bronchitis and pneumonia diagnoses. Mutant D55H displays 250% increase in H2O2 production and shows increased cytotoxicity to respiratory epithelium cells, mutant H51L displays 50% reduction in H2O2 production and shows decreased cytotoxicity to respiratory epithelium cells	Mycoplasma pneumoniae

Protein Variants

Protein Variants	Comment	Organism
D55H	mutant isolated from children and teens with bronchitis and pneumonia diagnoses, mutant displays 250% increase in H2O2 production. Mutant shows increased cytotoxicity to respiratory epithelium cells	Mycoplasma pneumoniae
H51L	mutant isolated from children and teens with bronchitis and pneumonia diagnoses, mutant displays 50% reduction in H2O2 production. Mutant shows decreased cytotoxicity to respiratory epithelium cells	Mycoplasma pneumoniae
L61V	mutant isolated from children and teens with bronchitis and pneumonia diagnoses, mutant displays no change in H2O2 production	Mycoplasma pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Mycoplasma pneumoniae	A0A0H3DPW7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sn-glycerol 3-phosphate + O2	-	Mycoplasma pneumoniae	glycerone phosphate + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
IhgO	-	Mycoplasma pneumoniae

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Release 2023.1 (January 2023)