Application | Comment | Organism |
---|---|---|
synthesis | the enzyme can be used for synthesis of optically pure 3-quinuclidinol. Optically pure 3-quinuclidinol is an important intermediate for the synthesis of various anticholinergic drugs. (R)-3-Quinuclidinol is used to synthesize muscarinic M1 or M3 receptor antagonists such as talsaclidine, revatropate, and solifenacin | Nocardia sp. WY1202 |
Cloned (Comment) | Organism |
---|---|
phylogenetic tree | Nocardia sp. WY1202 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-quinuclidinone + NADPH + H+ | Nocardia sp. WY1202 | stereospecific reduction of 3-quinuclidinone | (R)-3-quinuclidinol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nocardia sp. WY1202 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | apart from D-glucose and glycerol, various sugars and alcohols like maltose, sucrose, arabinose, mannitol, sorbitol are not utilized by strain WY1202 for growth | Nocardia sp. WY1202 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone | Nocardia sp. WY1202 | (R)-3-quinuclidinol + NADP+ | - |
? | |
3-quinuclidinone + NADPH + H+ | stereospecific reduction of 3-quinuclidinone with over 85-95% enantiomeric excess, effects of concentration of 3-quinuclidinone hydrochloride, overview | Nocardia sp. WY1202 | (R)-3-quinuclidinol + NADP+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Nocardia sp. WY1202 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Nocardia sp. WY1202 |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Nocardia sp. WY1202 |