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Literature summary for 1.1.1.95 extracted from

  • Fan, J.; Teng, X.; Liu, L.; Mattaini, K.R.; Looper, R.E.; Vander Heiden, M.G.; Rabinowitz, J.D.
    Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate (2015), ACS Chem. Biol., 10, 510-516.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
NADH with 2-oxoglutarate as cosubstrate, at pH 7.6 and 37°C Homo sapiens
0.004
-
NADH with oxaloacetate as cosubstrate, at pH 7.6 and 37°C Homo sapiens
0.022
-
NAD+ with 3-phospho-D-glycerate as cosubstrate, at pH 7.6 and 37°C Homo sapiens
0.26
-
3-phospho-D-glycerate at pH 7.6 and 37°C Homo sapiens
6.5
-
oxaloacetate at pH 7.6 and 37°C Homo sapiens
10.1
-
2-oxoglutarate at pH 7.6 and 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutarate + NADH + H+ Homo sapiens
-
D-2-hydroxyglutarate + NAD+
-
?
3-phospho-D-glycerate + NAD+ Homo sapiens
-
3-phosphonooxypyruvate + NADH + H+
-
?
additional information Homo sapiens no activity with pyruvate ?
-
?
oxaloacetate + NADH + H+ Homo sapiens
-
malate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-20 cell
-
Homo sapiens
-
MDA-MB-468 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + NADH + H+
-
Homo sapiens D-2-hydroxyglutarate + NAD+
-
?
3-phospho-D-glycerate + NAD+
-
Homo sapiens 3-phosphonooxypyruvate + NADH + H+
-
?
additional information no activity with pyruvate Homo sapiens ?
-
?
oxaloacetate + NADH + H+
-
Homo sapiens malate + NAD+
-
?

Synonyms

Synonyms Comment Organism
D-3-phosphoglycerate dehydrogenase
-
Homo sapiens
Phgdh
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.075
-
3-phospho-D-glycerate at pH 7.6 and 37°C Homo sapiens
0.078
-
2-oxoglutarate at pH 7.6 and 37°C Homo sapiens
0.177
-
oxaloacetate at pH 7.6 and 37°C Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens