Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
NADH | with 2-oxoglutarate as cosubstrate, at pH 7.6 and 37°C | Homo sapiens | |
0.004 | - |
NADH | with oxaloacetate as cosubstrate, at pH 7.6 and 37°C | Homo sapiens | |
0.022 | - |
NAD+ | with 3-phospho-D-glycerate as cosubstrate, at pH 7.6 and 37°C | Homo sapiens | |
0.26 | - |
3-phospho-D-glycerate | at pH 7.6 and 37°C | Homo sapiens | |
6.5 | - |
oxaloacetate | at pH 7.6 and 37°C | Homo sapiens | |
10.1 | - |
2-oxoglutarate | at pH 7.6 and 37°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + NADH + H+ | Homo sapiens | - |
D-2-hydroxyglutarate + NAD+ | - |
? | |
3-phospho-D-glycerate + NAD+ | Homo sapiens | - |
3-phosphonooxypyruvate + NADH + H+ | - |
? | |
additional information | Homo sapiens | no activity with pyruvate | ? | - |
? | |
oxaloacetate + NADH + H+ | Homo sapiens | - |
malate + NAD+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-20 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxoglutarate + NADH + H+ | - |
Homo sapiens | D-2-hydroxyglutarate + NAD+ | - |
? | |
3-phospho-D-glycerate + NAD+ | - |
Homo sapiens | 3-phosphonooxypyruvate + NADH + H+ | - |
? | |
additional information | no activity with pyruvate | Homo sapiens | ? | - |
? | |
oxaloacetate + NADH + H+ | - |
Homo sapiens | malate + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-3-phosphoglycerate dehydrogenase | - |
Homo sapiens |
Phgdh | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.075 | - |
3-phospho-D-glycerate | at pH 7.6 and 37°C | Homo sapiens | |
0.078 | - |
2-oxoglutarate | at pH 7.6 and 37°C | Homo sapiens | |
0.177 | - |
oxaloacetate | at pH 7.6 and 37°C | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |