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Literature summary for 1.1.1.94 extracted from

  • Frohlich, K.M.; Roberts, R.A.; Housley, N.A.; Audia, J.P.
    Rickettsia prowazekii uses an sn-glycerol-3-phosphate dehydrogenase and a novel dihydroxyacetone phosphate transport system to supply triose phosphate for phospholipid biosynthesis (2010), J. Bacteriol., 192, 4281-4288.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rickettsia prowazekii

Protein Variants

Protein Variants Comment Organism
additional information heterologous expression in Escherichia coli complements an Escherichia coli gpsA mutant Rickettsia prowazekii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.048
-
NADPH pH 7.4, temperature not specified in the publication Rickettsia prowazekii
0.528
-
glycerone phosphate cosubstrate NADPH, pH 7.4, temperature not specified in the publication Rickettsia prowazekii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36600
-
x * 36600, SDS-PAGE and calculated for His-tagged protein Rickettsia prowazekii

Organism

Organism UniProt Comment Textmining
Rickettsia prowazekii Q9ZDA0
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Rickettsia prowazekii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerone phosphate + NADH + H+
-
Rickettsia prowazekii sn-glycerol 3-phosphate + NAD+
-
r
glycerone phosphate + NADPH + H+ favoured reaction direction Rickettsia prowazekii sn-glycerol 3-phosphate + NADP+
-
r
sn-glycerol 3-phosphate + NADP+
-
Rickettsia prowazekii glycerone phosphate + NADPH + H+
-
r

Subunits

Subunits Comment Organism
? x * 36600, SDS-PAGE and calculated for His-tagged protein Rickettsia prowazekii

Synonyms

Synonyms Comment Organism
G3PDH
-
Rickettsia prowazekii
GpsA
-
Rickettsia prowazekii
RP442
-
Rickettsia prowazekii

Cofactor

Cofactor Comment Organism Structure
NADH NADPH is preferred over NADH as the cofactor Rickettsia prowazekii
NADPH NADPH is preferred over NADH as the cofactor Rickettsia prowazekii

General Information

General Information Comment Organism
physiological function Rickettsia prowazekii is unable to synthesize glycerone phosphate as a substrate for the GpsA enzymatic reaction. Purified Rickettsia prowazekii transports and incorporates glycerone phosphate into phospholipids, implicating a role for GpsA in vivo as part of a rickettsial G3P acquisition pathway for phospholipid biosynthesis Rickettsia prowazekii