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Literature summary for 1.1.1.94 extracted from

  • Edgar, J.R.; Bell, R.M.
    Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase (1978), J. Biol. Chem., 253, 6354-6363.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information existence of a naturally occurring feedback inhibition-resistant mutant Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
dihydroxyacetone phosphate noncompetitive versus NADP+ Escherichia coli
NADP+ competitive versus NADPH Escherichia coli
NADPH competitive versus NADP+ Escherichia coli
sn-glycerol-3-phosphate product inhibition at an allosteric, regulatory site, competitive versus dihydroxyacetone phosphate, noncompetitive versus NADPH, the wild-type enzyme is feedback inhibited Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics and bimolecular kinetic mechanism Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycerone phosphate + NAD(P)H + H+ Escherichia coli enzyme regulation, overview sn-glycerol 3-phosphate + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ bimolecular kinetic mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerone phosphate + NAD(P)H + H+ i.e. dihydroxyacetone phosphate Escherichia coli sn-glycerol 3-phosphate + NAD(P)+
-
r
glycerone phosphate + NAD(P)H + H+ enzyme regulation, overview Escherichia coli sn-glycerol 3-phosphate + NAD(P)+
-
r

Synonyms

Synonyms Comment Organism
sn-glycerol-3-phosphate dehydrogenase
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Escherichia coli
NADH
-
Escherichia coli
NADP+
-
Escherichia coli
NADPH
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Escherichia coli
0.0044
-
sn-glycerol-3-phosphate pH 7.4, 23°C, wild-type enzyme Escherichia coli
0.043
-
sn-glycerol-3-phosphate pH 7.4, 23°C, resistant mutant enzyme Escherichia coli