Cloned (Comment) | Organism |
---|---|
expressed in COS-M6a, monkey | Mesocricetus auratus |
expressed in UT-2, CHO-cells | Mesocricetus auratus |
Protein Variants | Comment | Organism |
---|---|---|
S871A | 150% of wild-type activity in 50 mM KCl | Mesocricetus auratus |
General Stability | Organism |
---|---|
stable to quick freezing and boiling | Mesocricetus auratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KF | - |
Mesocricetus auratus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | membrane-bound | Mesocricetus auratus | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | Mesocricetus auratus | mevalonate is required for cholesterol and isoprenoid synthesis | (R)-mevalonate + NAD+ + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
chinese hamster | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | near the C-terminus | Mesocricetus auratus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.922 | - |
wild-type enzyme, [14C]-mevalonate acylation | Mesocricetus auratus |
1.203 | - |
S871A [14C]-mevalonate acylation | Mesocricetus auratus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-mevalonate + CoA + 2 NAD+ | - |
Mesocricetus auratus | (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ | - |
? | |
(S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ | mevalonate is required for cholesterol and isoprenoid synthesis | Mesocricetus auratus | (R)-mevalonate + NAD+ + CoA | - |
? |