Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydroxy(methyl)propanedioic acid | - |
Staphylococcus aureus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | active site contains two divalent Mg2+ cations | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-2-acetolactate + NADPH | Staphylococcus aureus | - |
(2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(2S)-2-acetolactate + NADPH | Staphylococcus aureus NCTC 8325 | - |
(2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(S)-2-acetolactate + NADPH + H+ | Staphylococcus aureus | - |
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? | |
(S)-2-acetolactate + NADPH + H+ | Staphylococcus aureus NCTC 8325 | - |
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q2FWK4 | - |
- |
Staphylococcus aureus NCTC 8325 | Q2FWK4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2S)-2-acetolactate + NADPH | - |
Staphylococcus aureus | (2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(2S)-2-acetolactate + NADPH | - |
Staphylococcus aureus NCTC 8325 | (2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(2S)-2-acetolactate + NADPH + H+ | the reaction includes the initial deprotonation of the substrate C2 hydroxy group, bridged by the two Mg2+ ions, alkyl migration from the C2-alkoxide carbon atom to the C3-carbon | Staphylococcus aureus | (2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(2S)-2-acetolactate + NADPH + H+ | the reaction includes the initial deprotonation of the substrate C2 hydroxy group, bridged by the two Mg2+ ions, alkyl migration from the C2-alkoxide carbon atom to the C3-carbon | Staphylococcus aureus NCTC 8325 | (2R)-2,3-dihydroxyisovalerate + NADP+ | - |
? | |
(S)-2-acetolactate + NADPH + H+ | - |
Staphylococcus aureus | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? | |
(S)-2-acetolactate + NADPH + H+ | - |
Staphylococcus aureus NCTC 8325 | (2R)-2,3-dihydroxy-3-methylbutanoate + NADP+ | - |
? | |
2-glutaryl lactic acid + NADPH | - |
Staphylococcus aureus | ? + NADP+ | - |
? | |
2-glutaryl lactic acid + NADPH | - |
Staphylococcus aureus NCTC 8325 | ? + NADP+ | - |
? | |
2-tribromomethyl acetolactic acid + NADPH | - |
Staphylococcus aureus | ? + NADP+ | - |
? | |
2-tribromomethyl acetolactic acid + NADPH | - |
Staphylococcus aureus NCTC 8325 | ? + NADP+ | - |
? | |
2-trichloromethyl acetolactic acid + NADPH | - |
Staphylococcus aureus | ? + NADP+ | - |
? | |
2-trifluormethyl acetolactic acid + NADPH | - |
Staphylococcus aureus | ? + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KARI | - |
Staphylococcus aureus |
General Information | Comment | Organism |
---|---|---|
drug target | the enzyme is responsible for the second step of the biosynthesis of branched chain amino acids in plants and microorganisms and thus serves as a key inhibition target potentially without effects on mammals | Staphylococcus aureus |
metabolism | the enzyme serves as a key inhibition target potentially without effects on mammals | Staphylococcus aureus |
physiological function | the enzyme is responsible for the second step of the biosynthesis of branched chain amino acids in plants and microorganisms | Staphylococcus aureus |