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Literature summary for 1.1.1.8 extracted from

  • Li, H.; Rai, M.; Buddika, K.; Sterrett, M.; Luhur, A.; Mahmoudzadeh, N.; Julick, C.; Pletcher, R.; Chawla, G.; Gosney, C.; Burton, A.; Karty, J.; Montooth, K.; Sokol, N.; Tennessen, J.
    Lactate dehydrogenase and glycerol-3-phosphate dehydrogenase cooperatively regulate growth and carbohydrate metabolism during Drosophila melanogaster larval development (2019), Development, 146, dev175315 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Drosophila melanogaster P13706
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-

Source Tissue

Source Tissue Comment Organism Textmining
larva
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 Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
GPDH1
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 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function GPDH1 regulates larval NAD+/NADH redox balance and ATP levels. Larvae lacking both lactate dehydrogenase and G3P dehydrogenase (GPDH1) exhibit growth defects, synthetic lethality and decreased glycolytic flux, simultaneous loss of LDH and GPDH1 disrupts ATP homeostasis and glycolytic flux Drosophila melanogaster