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Literature summary for 1.1.1.8 extracted from

  • Orr, A.L.; Ashok, D.; Sarantos, M.R.; Ng, R.; Shi, T.; Gerencser, A.A.; Hughes, R.E.; Brand, M.D.
    Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase (2014), PLoS ONE, 9, e89938.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of the cytosolic NAD+-linked cGPDH enzyme by cell-permeant small-molecule inhibitors of mitochondrial mGPDH, EC 1.1.5.3, with a core benzimidazole-phenyl-succinamide structure Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-
soluble
-
Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycerol 3-phosphate + NAD+ Oryctolagus cuniculus
-
glycerone phosphate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus P08507
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation purified enzyme Oryctolagus cuniculus
-
skeletal muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycerol 3-phosphate + NAD+
-
Oryctolagus cuniculus glycerone phosphate + NADH + H+
-
r
sn-glycerol 3-phosphate + NAD+ NAD+-linked cGPDH can interconvert DHAP and glycerol 3-phosphate Oryctolagus cuniculus glycerone phosphate + NADH + H+
-
r

Synonyms

Synonyms Comment Organism
cGPdH
-
Oryctolagus cuniculus
cytosolic GPDH
-
Oryctolagus cuniculus
GPD1
-
Oryctolagus cuniculus

Temperature Optimum [┬░C]

Temperature Optimum [┬░C] Temperature Optimum Maximum [┬░C] Comment Organism
37
-
assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Oryctolagus cuniculus
NADH
-
Oryctolagus cuniculus