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Literature summary for 1.1.1.8 extracted from

  • Herrera-Valencia, V.A.; Macario-Gonzalez, L.A.; Casais-Molina, M.L.; Beltran-Aguilar, A.G.; Peraza-Echeverria, S.
    In silico cloning and characterization of the glycerol-3-phosphate dehydrogenase (GPDH) gene family in the green microalga Chlamydomonas reinhardtii (2012), Curr. Microbiol., 64, 477-485.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
genes CrGPDH1, CrGPDH2, and CrGPDH3, DNA and amino acid sequence determination and analysis, phylogenetic analysis Chlamydomonas reinhardtii

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Chlamydomonas reinhardtii 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sn-glycerol 3-phosphate + NAD+ Chlamydomonas reinhardtii
-
glycerone phosphate + NADH + H+
-
r
sn-glycerol 3-phosphate + NAD+ Chlamydomonas reinhardtii CC-125
-
glycerone phosphate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii
-
three GPDH genes, CrGPDH1, CrGPDH2, and CrGPDH3
-
Chlamydomonas reinhardtii CC-125
-
three GPDH genes, CrGPDH1, CrGPDH2, and CrGPDH3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sn-glycerol 3-phosphate + NAD+
-
Chlamydomonas reinhardtii glycerone phosphate + NADH + H+
-
r
sn-glycerol 3-phosphate + NAD+
-
Chlamydomonas reinhardtii CC-125 glycerone phosphate + NADH + H+
-
r

Subunits

Subunits Comment Organism
More each one of the three CrGPDHs has a bi-domain protein structure: a GPDH domain of about 350 amino acids located at the C terminus, and a phosphoserine phosphatase (SerB) domain of about 200 amino acids at the N terminus. The GPDH domain of all three CrGPDHs contains the conserved GSGAWA motif at residues 261-266 (CrGPDH1), 316-321 (CrGPDH2), and 267-272 (CrGPDH3), three-dimensional structures by homology modeling, based on the Homo sapiens GPD1 crystal structure, overview Chlamydomonas reinhardtii

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate dehydrogenase
-
Chlamydomonas reinhardtii
GPDH
-
Chlamydomonas reinhardtii
NAD+-GPDH
-
Chlamydomonas reinhardtii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Chlamydomonas reinhardtii
NADH
-
Chlamydomonas reinhardtii