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Literature summary for 1.1.1.62 extracted from

  • Purohit, A.; Tutill, H.J.; Day, J.M.; Chander, S.K.; Lawrence, H.R.; Allan, G.M.; Fischer, D.S.; Vicker, N.; Newman, S.P.; Potter, B.V.; Reed, M.J.
    The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer (2006), Mol. Cell. Endocrinol., 248, 199-203.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
16beta-m-pyridylmethylamidomethyl-2-methoxyoestrone IC50: 0.00029 mM Homo sapiens
2-methoxyoestrone IC50: 0.0024 mM Homo sapiens
equilin IC50: 0.0017 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NAD(P)H + H+ Homo sapiens 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-47D cell 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H + H+ 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours Homo sapiens estradiol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD1
-
Homo sapiens
17beta-hydroxysteroid dehydrogenase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00029
-
IC50: 0.00029 mM Homo sapiens 16beta-m-pyridylmethylamidomethyl-2-methoxyoestrone
0.0017
-
IC50: 0.0017 mM Homo sapiens equilin
0.0024
-
IC50: 0.0024 mM Homo sapiens 2-methoxyoestrone