Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-hydroxy-1,3,5(10)-triene-[17,16-c]-(5'-carboxylic acid)-pyrazole | 0.01 mM: 32% inhibition | Homo sapiens | |
3-hydroxy-1,3,5(10)-triene-[17,16-c]-(5'-hydroxymethyl)-pyrazole | 0.01 mM: 94% inhibition, IC50: 0.00095 mM | Homo sapiens | |
3-hydroxy-1,3,5(10)-triene-[17,16-c]-[5'-(carboxylic acid ethyl ester)]-pyrazole | 0.01 mM: 94% inhibition, IC50: 0.00185 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-isobutyl)-pyrazole | 0.01 mM: 77% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methoxyethyl)-pyrazole | 0.01 mM: 95% inhibition, IC50: 0.00053 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl acetate)-pyrazole | 0.01 mM: 95% inhibition, IC50: 0.00092 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl)-pyrazole | 0.01 mM: 94% inhibition, IC50: 0.00275 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-propionitrile)-pyrazole | 0.01 mM: 95% inhibition, IC50: 0.00073 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(2'-isobutyl)-pyrazole | 0.01 mM: 70% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(2'-methoxy-ethyl)-pyrazole | 0.01 mM: 83% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(2'-methyl acetate)-pyrazole | 0.01 mM: 79% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(2'-methyl)-pyrazole | 0.01 mM: 43% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(5'-ethylme-thylcarbamoyl)-pyrazole | 0.01 mM: 88% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(5'-isopropylcarbamoyl)-pyrazole | 0.01 mM: 57% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(5'-methyl)-pyrazole | 0.01 mM: 75% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(5'-methyl-carbamoyl)-pyrazole | 0.01 mM: 62% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(1''-methylpiperazin-4''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 50% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(1'-methylpyrrol-2''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 89% inhibition, IC50: 0.0023 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(5''-methylpyrazin-2''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 80% inhibition | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-2''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 93% inhibition, IC50: 0.00088 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylethyl)carbamoyl]-pyrazole | 0.01 mM: 99% inhibition, IC50: 0.0003 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 92% inhibition, IC50: 0.00078 mM | Homo sapiens | |
3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(tetrahydrofuran-2''-ylmethyl)carbamoyl]-pyrazole | 0.01 mM: 87% inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-47D cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NADPH + H+ | - |
Homo sapiens | estradiol-17beta + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
0.01 mM: 99% inhibition, IC50: 0.0003 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylethyl)carbamoyl]-pyrazole | |
0.00053 | - |
0.01 mM: 95% inhibition, IC50: 0.00053 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methoxyethyl)-pyrazole | |
0.00073 | - |
0.01 mM: 95% inhibition, IC50: 0.00073 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-propionitrile)-pyrazole | |
0.00078 | - |
0.01 mM: 92% inhibition, IC50: 0.00078 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-3''-ylmethyl)carbamoyl]-pyrazole | |
0.00088 | - |
0.01 mM: 93% inhibition, IC50: 0.00088 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(pyridin-2''-ylmethyl)carbamoyl]-pyrazole | |
0.00092 | - |
0.01 mM: 95% inhibition, IC50: 0.00092 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl acetate)-pyrazole | |
0.00095 | - |
0.01 mM: 94% inhibition, IC50: 0.00095 mM | Homo sapiens | 3-hydroxy-1,3,5(10)-triene-[17,16-c]-(5'-hydroxymethyl)-pyrazole | |
0.00185 | - |
0.01 mM: 94% inhibition, IC50: 0.00185 mM | Homo sapiens | 3-hydroxy-1,3,5(10)-triene-[17,16-c]-[5'-(carboxylic acid ethyl ester)]-pyrazole | |
0.0023 | - |
0.01 mM: 89% inhibition, IC50: 0.0023 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-[5'-(1'-methylpyrrol-2''-ylmethyl)carbamoyl]-pyrazole | |
0.00275 | - |
0.01 mM: 94% inhibition, IC50: 0.00275 mM | Homo sapiens | 3-hydroxy-estra-1,3,5(10)-triene-[17,16-c]-(1'-methyl)-pyrazole |