Application | Comment | Organism |
---|---|---|
medicine | type 1 17beta-hydroxysteroid dehydrogenase is an interesting biological target for designing drugs for the treatment of estrogen-sensitive diseases such as breast cancer | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HEK-293 cells transfected with human 17beta-HSD1-cDNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-(hexylsulfanyl)estra-1(10),2,4-triene-3,17beta-diol | 30% inhibition at 0.001 mM, reduction of estrone with NADH as cofactor | Homo sapiens | |
estrone | 92% inhibition at 0.001 mM, IC50: 0.00009 mM | Homo sapiens | |
N-butyl-6-[[(6beta,17beta)-17-hydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide | 38% inhibition at 0.001 mM, reduction of estrone with NADH as cofactor | Homo sapiens | |
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]oxy]-N-methylhexanamide | 73% inhibition at 0.001 mM, IC50: 0.0008 mM, reduction of estrone with NADH as cofactor | Homo sapiens | |
N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide | 92% inhibition at 0.001 mM, IC50: 0.00016 mM, reduction of estrone with NADH as cofactor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | Homo sapiens | type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol | estradiol-17beta + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol | Homo sapiens | estradiol-17beta + NAD(P)+ | - |
? | |
estrone + NADH + H+ | - |
Homo sapiens | estradiol-17beta + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD | - |
Homo sapiens |
type 1 17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | - |
92% inhibition at 0.001 mM, IC50: 0.00009 mM | Homo sapiens | estrone | |
0.00016 | - |
92% inhibition at 0.001 mM, IC50: 0.00016 mM, reduction of estrone with NADH as cofactor | Homo sapiens | N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]sulfanyl]-N-methylhexanamide | |
0.0008 | - |
73% inhibition at 0.001 mM, IC50: 0.0008 mM, reduction of estrone with NADH as cofactor | Homo sapiens | N-butyl-6-[[(6beta,17beta)-3,17-dihydroxyestra-1(10),2,4-trien-6-yl]oxy]-N-methylhexanamide |