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Literature summary for 1.1.1.62 extracted from

  • Blomquist, C.H.; Bonenfant, M.; McGinley, D.M.; Posalaky, Z.; Lakatua, D.J.; Tuli-Puri, S.; Bealka, D.G.; Tremblay, Y.
    Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms (2002), J. Steroid Biochem. Mol. Biol., 81, 343-351.
    View publication on PubMed
Search for more literature for 1.1.1.62

Inhibitors

Inhibitors Comment Organism Structure
diethylstilbestrol strong inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol 17beta-HSD5 Homo sapiens 5829
-
microsome 17beta-HSD2 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estradiol-17beta + NAD(P)+ Homo sapiens 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues estrone + NAD(P)H
-
 ?
estrone + NADPH + H+ Homo sapiens 17beta-HSD1, final step in the synthesis of active estrogens estradiol-17beta + NADP+
-
 ?
testosterone + NAD(P)+ Homo sapiens 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues 4-androstene-3,17-dione + NAD(P)H
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms 1, 2 and 5, 17beta-HSD1, 2 and 5
-

Reaction

Reaction Comment Organism Reaction ID
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ 17beta-HSD2 and 5 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD2 also has 20alpha-HSD activity Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
mucinous cystadenoma cell
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estradiol-17beta + NAD(P)+
-
 Homo sapiens estrone + NAD(P)H
-
 ?
estradiol-17beta + NAD(P)+ 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues Homo sapiens estrone + NAD(P)H
-
 ?
estrone + NADPH + H+ 17beta-HSD1, final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NADP+
-
 ?
testosterone + NAD(P)+ 17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues Homo sapiens 4-androstene-3,17-dione + NAD(P)H
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ most effective cofactor for 17beta-HSD 2 and 5 Homo sapiens
NADP+
-
 Homo sapiens
NADPH 17beta-HSD1 Homo sapiens