Literature summary for 1.1.1.62 extracted from

Zhu, S.J.; Li, Y.; Li, H.; Wang, Y.L.; Xiao, Z.J.; Vihko, P.; Piao, Y.S.
Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells (2002), J. Endocrinol., 172, 31-43.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
estrone + NADPH + H+	Homo sapiens	final step in the synthesis of active estrogens	estradiol-17beta + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform 1, 17HSD1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast	-	Homo sapiens	-
cytotrophoblast	cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid	Homo sapiens	-
JEG-3 cell	cultured cells, enzyme expression is stimulated with all-trans and 9-cis retinoic acid	Homo sapiens	-
placenta	-	Homo sapiens	-
T-47D cell	cultured cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
estrone + NADPH + H+	-	Homo sapiens	estradiol-17beta + NADP+	-	?
estrone + NADPH + H+	final step in the synthesis of active estrogens	Homo sapiens	estradiol-17beta + NADP+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)