Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
expression in Escherichia coli | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
androsterone | - |
Homo sapiens | |
0.0001 | - |
androsterone | - |
Rattus norvegicus | |
0.0001 | - |
5alpha-dihydrotestosterone | - |
Homo sapiens | |
0.0001 | - |
3alpha-adiol | - |
Rattus norvegicus | |
0.0028 | - |
testosterone | - |
Rattus norvegicus | |
0.0033 | - |
testosterone | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-dihydrotestosterone + NAD(P)H + H+ | Homo sapiens | discussion of physiological role | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | Rattus norvegicus | discussion of physiological role | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
prostate gland | - |
Homo sapiens | - |
prostate gland | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.005 | - |
- |
Rattus norvegicus |
0.011 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha-adiol + NAD(P)+ | - |
Homo sapiens | dihydrotestosterone + NAD(P)H | - |
r | |
3alpha-adiol + NAD(P)+ | - |
Rattus norvegicus | dihydrotestosterone + NAD(P)H | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Rattus norvegicus | 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Homo sapiens | (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | - |
Rattus norvegicus | (3beta,5alpha,17beta)-androstane-3,17-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | discussion of physiological role | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5alpha-dihydrotestosterone + NAD(P)H + H+ | discussion of physiological role | Rattus norvegicus | 5alpha-androstane-3alpha,17beta-diol + NAD(P)+ | - |
r | |
5beta-dihydrotestosterone + NAD(P)H | - |
Homo sapiens | 5beta-androstan-3alpha,17beta-diol + NAD(P)+ | - |
? | |
5beta-dihydrotestosterone + NAD(P)H | - |
Rattus norvegicus | 5beta-androstan-3alpha,17beta-diol + NAD(P)+ | - |
? | |
androsterone + NAD(P)+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NAD(P)H | - |
r | |
androsterone + NAD(P)+ | - |
Rattus norvegicus | 5alpha-androstan-3,17-dione + NAD(P)H | - |
r | |
estradiol + NAD(P)H | - |
Homo sapiens | estrone + NAD(P)+ | - |
? | |
estradiol + NAD(P)H | - |
Rattus norvegicus | estrone + NAD(P)+ | - |
? | |
testosterone + NAD(P)+ | - |
Homo sapiens | androstenedione + NAD(P)H + H+ | - |
? | |
testosterone + NAD(P)+ | - |
Rattus norvegicus | androstenedione + NAD(P)H + H+ | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0167 | - |
stanolone | - |
Homo sapiens | |
0.0333 | - |
androsterone | - |
Rattus norvegicus | |
0.0833 | - |
3alpha-adiol | - |
Rattus norvegicus | |
0.133 | - |
androsterone | - |
Homo sapiens | |
0.183 | - |
3alpha-adiol | - |
Homo sapiens |