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Literature summary for 1.1.1.44 extracted from

  • Bhanot, H.; Weisberg, E.L.; Reddy, M.M.; Nonami, A.; Neuberg, D.; Stone, R.M.; Podar, K.; Salgia, R.; Griffin, J.D.; Sattler, M.
    Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming (2017), Oncotarget, 8, 67639-67650 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P52209
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Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell
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 Homo sapiens
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General Information

General Information Comment Organism
drug target targeting 6-phosphogluconate dehydrogenase (6PGD) and NADPH production is sufficient to block growth of acute myeloid leukemia cell lines resistant to the chemotherapeutics daunorubicin and cytarabine. Stromal cell-mediated resistance to targeted inhibition of oncogenic FLT3 kinase activity by quizartinib is circumvented by 6PGD knockdown Homo sapiens
physiological function acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming Homo sapiens