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Literature summary for 1.1.1.413 extracted from

  • Shikura, N.; Yamamura, J.; Nihira, T.
    barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species (2002), J. Bacteriol., 184, 5151-5157 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptomyces virginiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0111
-
6-dehydro-Virginiae butanolide-A at pH 7.5 and 25°C Streptomyces virginiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
gel filtration Streptomyces virginiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-dehydro-Virginiae butanolide-A + NADPH + H+ Streptomyces virginiae
-
(2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?
6-dehydro-Virginiae butanolide-A + NADPH + H+ Streptomyces virginiae MAFF 10-06014
-
(2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces virginiae
-
-
-
Streptomyces virginiae MAFF 10-06014
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-heptanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ 88.9% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
3-heptanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ 88.9% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae MAFF 10-06014 ?
-
?
3-hexanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ 102% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
3-hexanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ 102% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae MAFF 10-06014 ?
-
?
4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one + NADPH + H+ 83.3% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one + NADPH + H+ 83.3% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae MAFF 10-06014 ?
-
?
4-(hydroxymethyl)-3-nonanoyloxolan-2-one + NADPH + H+ 75.3% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
4-(hydroxymethyl)-3-octanoyloxolan-2-one + NADPH + H+ 82.8% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
4-(hydroxymethyl)-3-pentanoyloxolan-2-one + NADPH + H+ 65.7% activity compared to 6-dehydro-Virginiae butanolide-A Streptomyces virginiae ?
-
?
6-dehydro-Virginiae butanolide-A + NADPH + H+
-
Streptomyces virginiae (2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?
6-dehydro-Virginiae butanolide-A + NADPH + H+ 100% activity Streptomyces virginiae (2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?
6-dehydro-Virginiae butanolide-A + NADPH + H+
-
Streptomyces virginiae MAFF 10-06014 (2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?
6-dehydro-Virginiae butanolide-A + NADPH + H+ 100% activity Streptomyces virginiae MAFF 10-06014 (2R,3R,6S)-Virginiae butanolide-A + NADP+
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 27000, SDS-PAGE Streptomyces virginiae
homodimer 2 * 27095, calculated from amino acid sequence Streptomyces virginiae

Synonyms

Synonyms Comment Organism
BARS1
-
Streptomyces virginiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Streptomyces virginiae

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
35 50 there is 80% loss and complete loss of activity after 30 min of incubation at 35°C and at 40 to 50°C, respectively Streptomyces virginiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Streptomyces virginiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Streptomyces virginiae