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Literature summary for 1.1.1.40 extracted from

  • Chen, Q.; Wang, B.; Ding, H.; Zhang, J.; Li, S.
    Review The role of NADP-malic enzyme in plants under stress (2019), Plant Sci., 281, 206-212 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Arabidopsis thaliana 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NADP+ Arabidopsis thaliana
-
pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+ Arabidopsis thaliana
-
(S)-malate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NADP+
-
Arabidopsis thaliana pyruvate + CO2 + NADPH + H+
-
r
pyruvate + CO2 + NADPH + H+
-
Arabidopsis thaliana (S)-malate + NADP+
-
r

Synonyms

Synonyms Comment Organism
NADP-malic enzyme
-
Arabidopsis thaliana
NADP-ME
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Arabidopsis thaliana
NADPH
-
Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism the enzyme metabolizes malate, which is important for stabilizing cytoplasmic pH, controlling stomatal aperture, increasing resistance to aluminum excess and pathogens. Pyruvate, another product of the enzyme reaction, participates in the synthesis of defense compounds such as flavonoids and lignin, which are involved in stresses tolerance such as mechanical wounding and pathogen invasion. Moreover, the enzyme provides essential reductive coenzyme NADPH in the biosynthesis of flavonoids and lignin. On the other hand, NADPH is crucial for reactive oxygen species metabolizing systems such as the ascorbate-glutathione pathway and NADPH-dependent thioredoxin reductase, and is also required by apoplastic oxidative burst in most plant-pathogen interactions Arabidopsis thaliana
physiological function the enzyme plays important roles in diverse stress responses (pathogen infection, ozone stress, drought stress, salt stress, metal excess, temperature stress, wounding and UV radiation) Arabidopsis thaliana