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Literature summary for 1.1.1.37 extracted from

  • Hanse, E.A.; Ruan, C.; Kachman, M.; Wang, D.; Lowman, X.H.; Kelekar, A.
    Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer (2017), Oncogene, 36, 3915-3924 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.37

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Jurkat isoform MDH1 knock-out cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-malate + NAD+ Homo sapiens
-
 oxaloacetate + NADH + H+
-
 r
oxaloacetate + NADH + H+ Homo sapiens
-
 (S)-malate + NAD+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
lung squamous cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-malate + NAD+
-
 Homo sapiens oxaloacetate + NADH + H+
-
 r
oxaloacetate + NADH + H+
-
 Homo sapiens (S)-malate + NAD+
-
 r

Subunits

Subunits Comment Organism
? x * 37000, FLAG-tagged enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
cytosolic malate dehydrogenase 1
-
 Homo sapiens
Mdh1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism isoform MDH1 generates malate with carbons derived from glutamine, thus enabling utilization of glucose carbons for glycolysis and for biomass Homo sapiens
physiological function the enzyme isoform MDH1 plays a critical role in replenishing cytosolic NAD+ to support increased glycolysis during proliferation Homo sapiens