Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Sphingomonas sp. PAMC 26621 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | 1 mM, 57% loss of activity. 5 mM, 64.8% loss of activity | Sphingomonas sp. PAMC 26621 | |
Fe3+ | 1 mM, 47.3% loss of activity. 5 mM, 95.2% loss of activity | Sphingomonas sp. PAMC 26621 | |
Ni2+ | 1 mM, 71.4% loss of activity. Complete loss of activity | Sphingomonas sp. PAMC 26621 | |
Zn2+ | 1 mM, 57% loss of activity. 5 mM, 93% loss of activity | Sphingomonas sp. PAMC 26621 |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
D-glucose 6-phosphate | 20°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
0.145 | - |
D-glucose 6-phosphate | 30°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
0.675 | - |
D-glucose 6-phosphate | 20°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
4.3 | - |
D-glucose 6-phosphate | 30°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 5 mM, slight activiation | Sphingomonas sp. PAMC 26621 | |
Mg2+ | 5 mM, slight activiation | Sphingomonas sp. PAMC 26621 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | Sphingomonas sp. PAMC 26621 | - |
6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | Sphingomonas sp. PAMC 26621 | - |
6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sphingomonas sp. PAMC 26621 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sphingomonas sp. PAMC 26621 |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucose 6-phosphate + NAD+ | - |
Sphingomonas sp. PAMC 26621 | 6-phospho-D-glucono-1,5-lactone + NADH + H+ | - |
? | |
D-glucose 6-phosphate + NADP+ | - |
Sphingomonas sp. PAMC 26621 | 6-phospho-D-glucono-1,5-lactone + NADPH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G6PD | - |
Sphingomonas sp. PAMC 26621 |
glucose 6-phosphate dehydrogenase | - |
Sphingomonas sp. PAMC 26621 |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
NAD+-linked reaction | Sphingomonas sp. PAMC 26621 |
30 | - |
NADP+-linked reaction | Sphingomonas sp. PAMC 26621 |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
4 | 20 | the secondary structure of the enzyme is maintained between 4-40°C, its activity and tertiary structure are better preserved between 4-20°C | Sphingomonas sp. PAMC 26621 |
60 | - |
20 min, complete loss of activity | Sphingomonas sp. PAMC 26621 |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
19.9 | - |
D-glucose 6-phosphate | 20°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
46.4 | - |
D-glucose 6-phosphate | 30°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
116.9 | - |
D-glucose 6-phosphate | 20°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
134.7 | - |
D-glucose 6-phosphate | 30°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | - |
Sphingomonas sp. PAMC 26621 |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Sphingomonas sp. PAMC 26621 | |
NADP+ | - |
Sphingomonas sp. PAMC 26621 |
General Information | Comment | Organism |
---|---|---|
physiological function | crucial regulatory enzyme in the oxidative pentose phosphate pathway that provides reductive potential in the form of NADPH, as well as carbon skeletons for the synthesis of macromolecules | Sphingomonas sp. PAMC 26621 |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10.8 | - |
D-glucose 6-phosphate | 30°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
29.5 | - |
D-glucose 6-phosphate | 20°C, NAD+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
899.2 | - |
D-glucose 6-phosphate | 20°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 | |
929 | - |
D-glucose 6-phosphate | 30°C, NADP+-linked reaction, pH not specified in the publication | Sphingomonas sp. PAMC 26621 |