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Literature summary for 1.1.1.357 extracted from

  • Rizner, T.; Lin, H.; Penning, T.
    Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells (2003), Chem. Biol. Interact., 143-144, 401-409.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-1 cells, PC-3 cells, and LNCaP cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-dihydrotestosterone + NAD(P)H + H+ Homo sapiens
-
3alpha-androstanediol + NAD(P)+
-
?
additional information Homo sapiens isoform AKR1C2 functions preferentially as a 3-ketosteroid reductase ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha-androstanediol + NAD+
-
Homo sapiens 5alpha-dihydrotestosterone + NADH + H+
-
?
5alpha-dihydrotestosterone + NAD(P)H + H+
-
Homo sapiens 3alpha-androstanediol + NAD(P)+
-
?
5alpha-dihydrotestosterone + NADPH + H+
-
Homo sapiens 3alpha-androstanediol + NADP+
-
?
additional information isoform AKR1C2 functions preferentially as a 3-ketosteroid reductase Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AKR1C2 isoform Homo sapiens
bile acid binding protein
-
Homo sapiens
type 3 3alpha-hydroxysteroid dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ preferred cofactor for oxidation Homo sapiens
NADPH preferred cofactor for reduction Homo sapiens