Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Streptomyces kanamyceticus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-dehydrokanamycin A + NADPH + H+ | Streptomyces kanamyceticus | the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic | kanamycin A + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces kanamyceticus | Q2MFU6 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Streptomyces kanamyceticus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-dehydrokanamycin A + NADPH + H+ | the enzyme is involved in the conversion of kanamycin B to kanamycin A. Kanamycin is a clinically important aminoglycoside antibiotic | Streptomyces kanamyceticus | kanamycin A + NADP+ | - |
? | |
2'-dehydrokanamycin A + NADPH + H+ | i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-a-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside | Streptomyces kanamyceticus | kanamycin A + NADP+ | i.e. (1S,2R,3R,4S,6R)-4,6-diamino-3-[(6-amino-6-deoxy-a-D-arabino-hexopyranosyl-2-ulose)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside | ? |
Synonyms | Comment | Organism |
---|---|---|
kanK | - |
Streptomyces kanamyceticus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Streptomyces kanamyceticus |