Literature summary for 1.1.1.34 extracted from

Zhang, G.; Wu, Y.; Haq Muhammad, Z.U.; Yang, Y.; Yu, J.; Zhang, J.; Yang, D.
cDNA cloning, prokaryotic expression and functional analysis of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) in Pogostemon cablin (2019), Protein Expr. Purif., 163, 105454 .

Search for more literature for 1.1.1.34

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli Rosetta (DE3) cells	Pogostemon cablin

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	Pogostemon cablin	-	(R)-mevalonate + CoA + 2 NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Pogostemon cablin	A0A5J6DKK9	patchouli	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography	Pogostemon cablin

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+	-	Pogostemon cablin	(R)-mevalonate + CoA + 2 NADP+	-	?

Subunits

Subunits	Comment	Organism
?	x * 38000, SDS-PAGE	Pogostemon cablin

Synonyms

Synonyms	Comment	Organism
3-hydroxy-3-methylglutaryl coenzyme A reductase	-	Pogostemon cablin
HMGCR1	-	Pogostemon cablin

General Information

General Information	Comment	Organism
malfunction	the enzyme is important in the biosynthesis of terpenoids such as patchouli alcohol	Pogostemon cablin

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Release 2023.1 (January 2023)