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Literature summary for 1.1.1.34 extracted from

  • Costa, C.H.S.; Oliveira, A.R.S.; Dos Santos, A.M.; da Costa, K.S.; Lima, A.H.L.E.; Alves, C.N.; Lameira, J.
    Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding (2019), J. Biomol. Struct. Dyn., 37, 4374-4383 .
    View publication on PubMed
Search for more literature for 1.1.1.34

Protein Variants

Protein Variants Comment Organism
S872D the mutation reduces the catalytic activity of the enzyme similarly to that of the phosphorylated enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-mevalonate + CoA + 2 NADP+ Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
 (R)-mevalonate + CoA + 2 NADP+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P04035
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the enzyme is phosphorylated at Ser872 by AMP-activated protein kinase and reversibly dephosphorylated by phosphatase 2A Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-mevalonate + CoA + 2 NADP+
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Homo sapiens (R)-mevalonate + CoA + 2 NADP+
-
 r

Subunits

Subunits Comment Organism
homotetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl coenzyme A reductase
-
 Homo sapiens
HMG-CoA reductase
-
 Homo sapiens
HMGR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens