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Literature summary for 1.1.1.34 extracted from

  • Rui, X.; Caiqin, L.; Wangjin, L.; Juan, D.; Zehuai, W.; Jianguo, L.
    3-Hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis (2012), Gene, 498, 28-35.
    View publication on PubMed
Search for more literature for 1.1.1.34

Cloned(Commentary)

Cloned (Comment) Organism
genes LcHMG1 and LcHMG2, DNA and amino acid sequence determination and analysis, real-time quantitative RT-PCR expression analysis Litchi chinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Litchi chinensis
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 (R)-mevalonate + CoA + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Litchi chinensis
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 genes LcHMG1 and LcHMG2
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Source Tissue

Source Tissue Comment Organism Textmining
flower unfertilized female flowers Litchi chinensis
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fruit genes LcHMG1 and LcHMG2 exhibit distinct expression patterns during litchi fruit development. LcHMG1 expression is highest in the early stage of fruit development, correlated with the high level of cell division. Absolute levels of LcHMG1 expression vary among fruits of different pheno- or genotypes, with expression in large-fruited types reaching higher levels for longer duration compared to that in small-fruited types. LcHMG2 is most highly expressed in the late stage of fruit development, in association with biosynthesis of isoprenoid compounds required for later cell enlargement Litchi chinensis
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leaf
-
 Litchi chinensis
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additional information analysis of LcHMG1 and LcHMG2 expressions in various litchi tissues, developmental stages and genotypes, overview. Expression of LcHMG1 and LcHMG2 is universally detected in all the tissues analyzed, including unfertilized female flowers, fruit tissues, leaves, shoots, and roots but their expression level appears to vary from tissue to tissue, with the highest expression found in the young pericarp (39 DAA) and the lowest in the aged seed. High level of expression in young tissues compared to aged tissues for a given organ except root Litchi chinensis
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pericarp young Litchi chinensis
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root
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 Litchi chinensis
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seed
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 Litchi chinensis
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shoot
-
 Litchi chinensis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Litchi chinensis (R)-mevalonate + CoA + 2 NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl coenzyme A reductase 1
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 Litchi chinensis
HMG1
-
 Litchi chinensis
HMG2
-
 Litchi chinensis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Litchi chinensis

General Information

General Information Comment Organism
metabolism 3-hydroxy-3-methylglutaryl CoA reductase catalyzes the first committed step in the mevalonic acid (MVA) pathway for the biosynthesis of isoprenoids Litchi chinensis
physiological function HMG1 is highly associated with the cell division during the early stage of fruit development which determines the final fruit size in Litchi chinensis. LcHMG2 is involved in the late stage of fruit development, in association with biosynthesis of isoprenoid compounds required for later cell enlargement Litchi chinensis