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Literature summary for 1.1.1.34 extracted from

  • Vaupotic, T.; Plemenitas, A.
    Osmoadaptation-dependent activity of microsomal HMG-CoA reductase in the extremely halotolerant black yeast Hortaea werneckii is regulated by ubiquitination (2007), FEBS Lett., 581, 3391-3395.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions Hortaea werneckii

Inhibitors

Inhibitors Comment Organism Structure
additional information the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions Hortaea werneckii

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum isozyme Hmg2 Hortaea werneckii 5783
-
microsome
-
Hortaea werneckii
-
-
mitochondrion isozyme Hmg1 Hortaea werneckii 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Hortaea werneckii
-
(R)-mevalonate + CoA + 2 NADP+
-
r
additional information Hortaea werneckii ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Hortaea werneckii
-
salt-tolerant black yeast, strain MZKI B736, isozymes Hmg1 and Hmg2
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview Hortaea werneckii

Purification (Commentary)

Purification (Comment) Organism
isozymes Hmg1 and Hmg2 partially by subcellular fractionation Hortaea werneckii

Source Tissue

Source Tissue Comment Organism Textmining
additional information the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions, while the activity of the truncated mitochondrial Hmg1 is constant under different growth conditions Hortaea werneckii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Hortaea werneckii (R)-mevalonate + CoA + 2 NADP+
-
r
additional information ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview Hortaea werneckii ?
-
?

Synonyms

Synonyms Comment Organism
HMGR
-
Hortaea werneckii
microsomal HMG-CoA reductase
-
Hortaea werneckii

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Hortaea werneckii
NADPH
-
Hortaea werneckii