Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions | Hortaea werneckii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions | Hortaea werneckii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | isozyme Hmg2 | Hortaea werneckii | 5783 | - |
microsome | - |
Hortaea werneckii | - |
- |
mitochondrion | isozyme Hmg1 | Hortaea werneckii | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Hortaea werneckii | - |
(R)-mevalonate + CoA + 2 NADP+ | - |
r | |
additional information | Hortaea werneckii | ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hortaea werneckii | - |
salt-tolerant black yeast, strain MZKI B736, isozymes Hmg1 and Hmg2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview | Hortaea werneckii |
Purification (Comment) | Organism |
---|---|
isozymes Hmg1 and Hmg2 partially by subcellular fractionation | Hortaea werneckii |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the activity of microsomal isoyzme Hmg2 is highest under hypo-saline and extremely hyper-saline conditions, and down-regulated under optimal growth conditions, while the activity of the truncated mitochondrial Hmg1 is constant under different growth conditions | Hortaea werneckii | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Hortaea werneckii | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
additional information | ubiquitination and proteasomal degradation of microsomal, but not mitochondrial, HMGR isozymes depends on environmental salinity, overview | Hortaea werneckii | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HMGR | - |
Hortaea werneckii |
microsomal HMG-CoA reductase | - |
Hortaea werneckii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Hortaea werneckii | |
NADPH | - |
Hortaea werneckii |