Literature summary for 1.1.1.34 extracted from

Pak, V.V.; Koo, M.; Kim, M.J.; Yun, L.; Kwon, D.Y.
Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone (2008), Bioorg. Med. Chem., 16, 1309-1318.

Search for more literature for 1.1.1.34

Inhibitors

Inhibitors	Comment	Organism	Structure
F(4-fluoro)VAE	HMG-CoA competitive inhibitor	Rattus norvegicus
FVAE	HMG-CoA competitive inhibitor	Rattus norvegicus
GFPDGG	designed on the basis of the rigid peptide backbone, increases the inhibitory potency more than 300 times compared to the first isolated LPYP from soybean, overview	Rattus norvegicus
GFPEGG	HMG-CoA competitive inhibitor	Rattus norvegicus
GFPTGG	HMG-CoA competitive inhibitor; NADPH and HMG-CoA competitive inhibitor	Rattus norvegicus
GLPDGG	NADPH and HMG-CoA competitive inhibitor	Rattus norvegicus
GLPEGG	NADPH and HMG-CoA competitive inhibitor	Rattus norvegicus
GLPTGG	NADPH and HMG-CoA competitive inhibitor	Rattus norvegicus
IAVE	HMG-CoA competitive inhibitor	Rattus norvegicus
IAVP	NADPH competitive inhibitor	Rattus norvegicus
IAVPGEVA	isolated from soybean by pepsin	Rattus norvegicus
IVAE	HMG-CoA competitive inhibitor	Rattus norvegicus
LPYP	from soybean	Rattus norvegicus
YAVE	HMG-CoA competitive inhibitor	Rattus norvegicus
YVAE	HMG-CoA competitive inhibitor	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hydroxymethylglutaryl-CoA + NADPH + H+	Rattus norvegicus	-	mevalonate + NADP+ + CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hydroxymethylglutaryl-CoA + NADPH + H+	-	Rattus norvegicus	mevalonate + NADP+ + CoA	-	?

Synonyms

Synonyms	Comment	Organism
HMG-CoA reductase	-	Rattus norvegicus
HMGR	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0015	-	-	Rattus norvegicus	GFPDGG
0.0017	-	-	Rattus norvegicus	GFPEGG
0.0038	-	-	Rattus norvegicus	F(4-fluoro)VAE
0.0169	-	-	Rattus norvegicus	GFPTGG
0.0194	-	-	Rattus norvegicus	GLPTGG
0.0223	-	-	Rattus norvegicus	GLPDGG
0.0272	-	-	Rattus norvegicus	GLPEGG
0.0418	-	-	Rattus norvegicus	YVAE
0.0438	-	-	Rattus norvegicus	FVAE
0.0441	-	-	Rattus norvegicus	IVAE
0.0526	-	-	Rattus norvegicus	YAVE
0.0752	-	-	Rattus norvegicus	IAVE
0.097	-	-	Rattus norvegicus	IAVP
0.152	-	-	Rattus norvegicus	IAVPGEVA
0.484	-	-	Rattus norvegicus	LPYP

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Release 2023.1 (January 2023)