Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.34 extracted from

  • Suzuki, M.; Kamide, Y.; Nagata, N.; Seki, H.; Ohyama, K.; Kato, H.; Masuda, K.; Sato, S.; Kato, T.; Tabata, S.; Yoshida, S.; Muranaka, T.
    Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels (2004), Plant J., 37, 750-761.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of insertion mutants of the 2 isozymes leads to loss of enzyme function, the hmg1 mutant plants show an altered phenotype with dwarfing, early senescence, male sterility, and both mutants of hmg1 and hmg2 show reduced sterol levels, the mutants are more sensitive to the inhibitor lovastatin and squalestatin, overview Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
lovastatin
-
Arabidopsis thaliana
squalestatin mutant plants, not wild-type plants, become sterile Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Arabidopsis thaliana enzyme is essential for sterol biosynthesis (R)-mevalonate + CoA + 2 NADP+
-
r
additional information Arabidopsis thaliana phytosterol biosynthetic pathway, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
2 genes hmg1 and hmg2 encode 2 isozymes HMG1 and HMG2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Arabidopsis thaliana (R)-mevalonate + CoA + 2 NADP+
-
r
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ enzyme is essential for sterol biosynthesis Arabidopsis thaliana (R)-mevalonate + CoA + 2 NADP+
-
r
additional information phytosterol biosynthetic pathway, overview Arabidopsis thaliana ?
-
?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1
-
Arabidopsis thaliana
HMG1
-
Arabidopsis thaliana
HMG2
-
Arabidopsis thaliana
HMGR
-
Arabidopsis thaliana