Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of insertion mutants of the 2 isozymes leads to loss of enzyme function, the hmg1 mutant plants show an altered phenotype with dwarfing, early senescence, male sterility, and both mutants of hmg1 and hmg2 show reduced sterol levels, the mutants are more sensitive to the inhibitor lovastatin and squalestatin, overview | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lovastatin | - |
Arabidopsis thaliana | |
squalestatin | mutant plants, not wild-type plants, become sterile | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | Arabidopsis thaliana | enzyme is essential for sterol biosynthesis | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
additional information | Arabidopsis thaliana | phytosterol biosynthetic pathway, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
2 genes hmg1 and hmg2 encode 2 isozymes HMG1 and HMG2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | - |
Arabidopsis thaliana | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ | enzyme is essential for sterol biosynthesis | Arabidopsis thaliana | (R)-mevalonate + CoA + 2 NADP+ | - |
r | |
additional information | phytosterol biosynthetic pathway, overview | Arabidopsis thaliana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1 | - |
Arabidopsis thaliana |
HMG1 | - |
Arabidopsis thaliana |
HMG2 | - |
Arabidopsis thaliana |
HMGR | - |
Arabidopsis thaliana |