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Literature summary for 1.1.1.34 extracted from

  • Holmberg, N.; Harker, M.; Wallace, A.D.; Clayton, J.C.; Gibbard, C.L.; Safford, R.
    Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols (2003), Plant J., 36, 12-20.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
construction of a N-terminally truncated enzyme, comprising the catalytic site, and subcloning into Escherichia coli strain DH5alpha Hevea brasiliensis

Protein Variants

Protein Variants Comment Organism
additional information coexpression of N-terminal truncated Hevea brasiliensis (S)-3-hydroxy-3-methylglutaryl CoA reductase and tobacco C24-sterol methyltransferase type 1 in transgenic Nicotiana tabacum plants enhances carbon flux towards end-product sterols, expression under control of both seed-specific and constitutive promotors leads to enhancement of sterol accumulation by 2.5 and 2.1fold, respectively, analysis of the sterol spectrum, overview Hevea brasiliensis

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum located on the cytoplasmic site, integrated into the membrane Hevea brasiliensis 5783
-
membrane integral Hevea brasiliensis 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Hevea brasiliensis
-
(R)-mevalonate + CoA + 2 NADP+
-
?
additional information Hevea brasiliensis enzyme plays a central role in sterol biosynthesis, investigation of the physiological regulation, 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 work in concert to control carbon flux into end-product sterols ?
-
?

Organism

Organism UniProt Comment Textmining
Hevea brasiliensis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
Hevea brasiliensis (R)-mevalonate + CoA + 2 NADP+
-
?
additional information enzyme plays a central role in sterol biosynthesis, investigation of the physiological regulation, 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 work in concert to control carbon flux into end-product sterols Hevea brasiliensis ?
-
?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl CoA reductase
-
Hevea brasiliensis
HMGR
-
Hevea brasiliensis