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Literature summary for 1.1.1.313 extracted from

  • Zhou, Y.; Wei, Y.; Nanjaraj Urs, A.N.; Lin, L.; Xu, T.; Hu, Y.; Ang, E.L.; Zhao, H.; Yuchi, Z.; Zhang, Y.
    Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense (2019), Biosci. Rep., 39, BSR20190715 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene isfD, genetic structure Chromohalobacter salexigens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens
-
isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens DSM 3043
-
isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens ATCC BAA-138
-
isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens NCIMB 13768
-
isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens 1H11
-
isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+ Chromohalobacter salexigens CIP 106854
-
isethionate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Chromohalobacter salexigens Q1R183
-
-
Chromohalobacter salexigens 1H11 Q1R183
-
-
Chromohalobacter salexigens ATCC BAA-138 Q1R183
-
-
Chromohalobacter salexigens CIP 106854 Q1R183
-
-
Chromohalobacter salexigens DSM 3043 Q1R183
-
-
Chromohalobacter salexigens NCIMB 13768 Q1R183
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens DSM 3043 isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens ATCC BAA-138 isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens NCIMB 13768 isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens 1H11 isethionate + NADP+
-
r
2-sulfoacetaldehyde + NADPH + H+
-
Chromohalobacter salexigens CIP 106854 isethionate + NADP+
-
r

Synonyms

Synonyms Comment Organism
IsfD
-
Chromohalobacter salexigens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Chromohalobacter salexigens
NADPH
-
Chromohalobacter salexigens

General Information

General Information Comment Organism
evolution the enzyme sulfoacetaldehyde reductase IsfD belongs to the short-chain dehydrogenase/reductase (SDR) family Chromohalobacter salexigens
metabolism in the pathway, taurine is imported by a taurine ABC transporter (TauABC), and converted into sulfoacetaldehyde by taurine:oxoglutarate aminotransferase (Toa), generating glutamate as an intermediate for nitrogen metabolism. The NADPH-dependent sulfoacetaldehyde reductase (IsfD), belonging to the SDR family, generates isethionate as a waste produce, which is exported by the putative isethionate exporter (IsfE) Chromohalobacter salexigens
physiological function hydroxyethylsulfonate (isethionate (Ise)) is generated by the sulfoacetaldehyde reductases from human gut bacteria. Isethionate is thought to be derived from aminoethylsulfonate (taurine), as a byproduct of taurine nitrogen assimilation by certain anaerobic bacteria inhabiting the taurine-rich mammalian gut Chromohalobacter salexigens