Cloned (Comment) | Organism |
---|---|
gene isfD, genetic structure | Chromohalobacter salexigens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens | - |
isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens DSM 3043 | - |
isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens ATCC BAA-138 | - |
isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens NCIMB 13768 | - |
isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens 1H11 | - |
isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | Chromohalobacter salexigens CIP 106854 | - |
isethionate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chromohalobacter salexigens | Q1R183 | - |
- |
Chromohalobacter salexigens 1H11 | Q1R183 | - |
- |
Chromohalobacter salexigens ATCC BAA-138 | Q1R183 | - |
- |
Chromohalobacter salexigens CIP 106854 | Q1R183 | - |
- |
Chromohalobacter salexigens DSM 3043 | Q1R183 | - |
- |
Chromohalobacter salexigens NCIMB 13768 | Q1R183 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens | isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens DSM 3043 | isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens ATCC BAA-138 | isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens NCIMB 13768 | isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens 1H11 | isethionate + NADP+ | - |
r | |
2-sulfoacetaldehyde + NADPH + H+ | - |
Chromohalobacter salexigens CIP 106854 | isethionate + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
IsfD | - |
Chromohalobacter salexigens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Chromohalobacter salexigens | |
NADPH | - |
Chromohalobacter salexigens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme sulfoacetaldehyde reductase IsfD belongs to the short-chain dehydrogenase/reductase (SDR) family | Chromohalobacter salexigens |
metabolism | in the pathway, taurine is imported by a taurine ABC transporter (TauABC), and converted into sulfoacetaldehyde by taurine:oxoglutarate aminotransferase (Toa), generating glutamate as an intermediate for nitrogen metabolism. The NADPH-dependent sulfoacetaldehyde reductase (IsfD), belonging to the SDR family, generates isethionate as a waste produce, which is exported by the putative isethionate exporter (IsfE) | Chromohalobacter salexigens |
physiological function | hydroxyethylsulfonate (isethionate (Ise)) is generated by the sulfoacetaldehyde reductases from human gut bacteria. Isethionate is thought to be derived from aminoethylsulfonate (taurine), as a byproduct of taurine nitrogen assimilation by certain anaerobic bacteria inhabiting the taurine-rich mammalian gut | Chromohalobacter salexigens |