Protein Variants | Comment | Organism |
---|---|---|
additional information | lentiviral-mediated shRNA efficiently inhibits RDH10 expression. RDH10 knockdown impairs glioma cell proliferation in vitro | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NADPH + H+ | Homo sapiens | - |
all-trans-retinol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8IZV5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | high RDH10 expression level, 13.89%, 43.59%, 70.59%, and 90.24% expression of RDH10 in glioma of grade I, II, III, and IV (WHO grading), respectively | Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinal + NADPH + H+ | - |
Homo sapiens | all-trans-retinol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDH10 | - |
Homo sapiens |
retinol dehydrogenase-10 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | retinol dehydrogenase-10 (RDH10) is a member of the short-chain dehydrogenase/reductase family | Homo sapiens |
malfunction | shRNA-mediated RDH10 knockdown induces glioma cell cycle arrest, impairs glioma cell proliferation in vitro, and promotes glioma apoptosis. RDH10 knockdown significantly represses several key cancer pathways including TWEAK, TNFR1 and P53. RDH10 knockdown inhibits glioma cell growth by down-regulating the TWEAK-NF-kappaB axis | Homo sapiens |
physiological function | retinol dehydrogenase-10 (RDH10) plays an important role in retinoic acid (RA) synthesis, and it promotes development and progression of human glioma via the TWEAK-NF-kappaB axis. RDH10 is highly expressed in human gliomas, and its expression correlates with tumor grade and patient survival times, RDH10 expression is associated with development and progression of human glioma. RDH10 is overexpressed in human gliomas and predicts a high grade and poor prognosis. RDH10 regulates the cell cycle progression, as its loss causes an S and G2/M phase arrest, RDH10 regulates expression of glioma genes, it affects expression of genes involved in cancer, apoptosis, growth and proliferation, motility, and cell cycle | Homo sapiens |