Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R)-2,3,4-trihydroxybutyl dihydrogen phosphate | IC50: 0.310 mM | Escherichia coli | |
(2R,3R)-4-amino-2,3-dihydroxybutyl dihydrogen phosphate | very weak inhibitor, IC50: 5 mM, above | Escherichia coli | |
(2R,3S)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate | very weak inhibitor, IC50: 5 mM, above | Escherichia coli | |
(2R,3S)-4-amino-2,3-dihydroxy-4-oxobutyl dihydrogen phosphate | IC50: 0.253 mM | Escherichia coli | |
(2S,3R)-2,3-dihydroxy-4-phosphonooxybutyric acid | IC50: 0.551 mM | Escherichia coli | |
(2S,3R)-methyl 2,3-dihydroxy-4-phosphonooxybutyrate | IC50: 1.024 mM | Escherichia coli | |
fosmidomycin | a phosphonic metabolite from Streptomyces rubellomurinus | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.081 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant His-tagged enzyme | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | Escherichia coli | involved in the biosynthesis of isopentenylphosphate | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | involved in the biosynthesis of isopentenylphosphate | Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? | |
1-deoxy-D-xylulose 5-phosphate + NADPH + H+ | i.e. DXP | Escherichia coli | 2-C-methyl-D-erythritol 4-phosphate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MEP synthase | - |
Escherichia coli |
methylerythritol phosphate synthase | - |
Escherichia coli |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
33 | - |
1-deoxy-D-xylulose 5-phosphate | pH 7.6, 37°C, recombinant His-tagged enzyme | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000021 | - |
fosmidomycin | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.253 | - |
IC50: 0.253 mM | Escherichia coli | (2R,3S)-4-amino-2,3-dihydroxy-4-oxobutyl dihydrogen phosphate | |
0.31 | - |
IC50: 0.310 mM | Escherichia coli | (2R,3R)-2,3,4-trihydroxybutyl dihydrogen phosphate | |
0.551 | - |
IC50: 0.551 mM | Escherichia coli | (2S,3R)-2,3-dihydroxy-4-phosphonooxybutyric acid | |
1.024 | - |
IC50: 1.024 mM | Escherichia coli | (2S,3R)-methyl 2,3-dihydroxy-4-phosphonooxybutyrate | |
5 | - |
very weak inhibitor, IC50: 5 mM, above | Escherichia coli | (2R,3S)-2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrogen phosphate | |
5 | - |
very weak inhibitor, IC50: 5 mM, above | Escherichia coli | (2R,3R)-4-amino-2,3-dihydroxybutyl dihydrogen phosphate |