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Literature summary for 1.1.1.248 extracted from

  • Wijekoon, C.P.; Facchini, P.J.
    Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing (2012), Plant J., 69, 1052-1063.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
real-time quantitative PCR expression analysis Papaver somniferum

Protein Variants

Protein Variants Comment Organism
additional information specific virus-induced gene silencing as a functional genomics tool to investigate the regulation of morphine biosynthesis via a systematic reduction in enzyme levels responsible for the final six steps in the pathway, overview. Reduced SalR protein levels correlate with lower morphine levels and a substantial increase in the accumulation of salutaridine Papaver somniferum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
salutaridine + NADPH + H+ Papaver somniferum
-
salutaridinol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Papaver somniferum
-
gene salR
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
salutaridine + NADPH + H+
-
Papaver somniferum salutaridinol + NADP+
-
r

Synonyms

Synonyms Comment Organism
SalR
-
Papaver somniferum
salutaridine reductase
-
Papaver somniferum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Papaver somniferum
NADPH
-
Papaver somniferum

General Information

General Information Comment Organism
malfunction reduced SalR protein levels correlate with lower morphine levels and a substantial increase in the accumulation of salutaridine. Morphine biosynthesis can be perturbed at each of the six final steps Papaver somniferum
metabolism the enzyme catalyzes a step in the morphinan alkaloid pathway, benzylisoquinoline alkaloid biosynthesis in opium poppy from (R)-reticuline to morphine overview. Morphine biosynthesis can be perturbed at each of the six final steps Papaver somniferum