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Literature summary for 1.1.1.213 extracted from

  • Uwai, K.; Konno, N.; Kitamura, S.; Ohta, S.; Takeshita, M.
    Purification and characterization of rat liver enzyme catalyzing stereoselective reduction of acetylpyridines (2005), Chirality, 17, 494-500.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information stereoselectivity, kinetics Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33500
-
1 * 33500, SDS-PAGE Rattus norvegicus
34600
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-acetylpyridine + NADPH + H+ Rattus norvegicus
-
(S)-1-(4-pyridyl)ethanol + NADP+
-
?
acetophenone + NADPH + H+ Rattus norvegicus
-
1-phenylethanol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Wistar rats
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme 73.3fold from liver by ammonium sulfate, anion-exchange chromatography, gel filtration, and affinity chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
9540
-
purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetylpyridine + NADPH stereoselective catalysis producing mainly the (S)-alcohols Rattus norvegicus 1-(2-pyridyl)ethanol + NADP+
-
?
3-acetylpyridine + NADPH low activity, stereoselective catalysis producing mainly the (S)-alcohols Rattus norvegicus 1-(3-pyridyl)ethanol + NADP+
-
?
4-acetylpyridine + NADPH + H+
-
Rattus norvegicus (S)-1-(4-pyridyl)ethanol + NADP+
-
?
4-acetylpyridine + NADPH + H+ stereoselective catalysis producing mainly the (S)-alcohols Rattus norvegicus 1-(4-pyridyl)ethanol + NADP+
-
?
acetophenone + NADPH + H+
-
Rattus norvegicus 1-phenylethanol + NADP+
-
?
additional information no activity with acetylpyrroles Rattus norvegicus ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 33500, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
3alpha-HSD
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus