Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-O-Galloyl-beta-D-glucose | i.e. beta-glucogallin or BGG, a major component of the Emblica officinalis medicinal plant, and a stable, potent, and specific inhibitor of aldose reductase, noncompetitive inhibition through binding the active site of AKR1B1, occupying both the anionic and the specificity pockets | Homo sapiens | |
1-O-Galloyl-beta-D-glucose | i.e. beta-glucogallin or BGG, a major component of the Emblica officinalis medicinal plant, and a stable, potent, and specific inhibitor of aldose reductase, noncompetitive inhibition through binding the active site of AKR1B1, occupying both the anionic and the specificity pockets | Mus musculus | |
additional information | no inhibition by the triazole 1-(beta-D-glucopyranosyl)-4-(3,4,5-trihydroxyphenyl)-1,2,3-triazole, the amide N-phenylacetyl beta-D-glucopyranosylamine, and the glycosides of beta-glucogallin, 2-(3,4,5-trihydroxyphenyl)ethyl beta-D-glucopyranoside, [1-(3,4,5-trihydroxybenzyl)-1,2,3-triazole-4-yl]methyl beta-D-glucopyranoside, and 3-(3,4,5-trihydroxyphenyl)propyl beta-D-glucopyranoside, synthesis and evaluation, overview | Homo sapiens | |
additional information | no inhibition by the triazole 1-(beta-D-glucopyranosyl)-4-(3,4,5-trihydroxyphenyl)-1,2,3-triazole, the amide N-phenylacetyl beta-D-glucopyranosylamine, and the glycosides of beta-glucogallin, 2-(3,4,5-trihydroxyphenyl)ethyl beta-D-glucopyranoside, [1-(3,4,5-trihydroxybenzyl)-1,2,3-triazole-4-yl]methyl beta-D-glucopyranoside, and 3-(3,4,5-trihydroxyphenyl)propyl beta-D-glucopyranoside, synthesis and evaluation, overview | Mus musculus | |
N-galloyl beta-D-glucopyranosylamine | - |
Homo sapiens | |
N-galloyl beta-D-glucopyranosylamine | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
? | |
glyceraldehyde + NADPH + H+ | Mus musculus | - |
glycerol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15121 | - |
- |
Mus musculus | P45376 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Mus musculus | - |
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
? | |
glyceraldehyde + NADPH + H+ | - |
Mus musculus | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AKR1B1 | - |
Homo sapiens |
AKR1B1 | - |
Mus musculus |
aldose reductase | - |
Homo sapiens |
aldose reductase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Homo sapiens | |
NADPH | dependent on | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.008 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-O-Galloyl-beta-D-glucose | |
0.009 | - |
pH and temperature not specified in the publication | Homo sapiens | N-galloyl beta-D-glucopyranosylamine |
General Information | Comment | Organism |
---|---|---|
evolution | aldose reductase (AKR1B1) is a member of the aldo-keto reductase superfamily | Mus musculus |
evolution | human aldose reductase (AKR1B1) is a member of the aldo-keto reductase superfamily, which consists of 15 families, 3 of which are mammalian containing the thirteen human aldo-keto reductase enzymes currently identified | Homo sapiens |
metabolism | AKR1B1 functions in the polyol pathway as an NADPH-dependent enzyme, catalyzing the reduction of glucose to sorbitol, which is then converted to fructose by sorbitol dehydrogenase | Homo sapiens |
metabolism | AKR1B1 functions in the polyol pathway as an NADPH-dependent enzyme, catalyzing the reduction of glucose to sorbitol, which is then converted to fructose by sorbitol dehydrogenase | Mus musculus |